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Immune-Mediated Diseases and Deficiencies

Octapharma develops and manufactures high-purity human immunoglobulin products for treating immune-mediated diseases and deficiencies.

 

The immune system plays a key role in numerous conditions. In so-called immune deficiencies, the patient is prone to severe infections due to a lack of naturally occurring protective antibodies (immunoglobulins). Such patients need replacement of the missing immunoglobulins in order to protect them against infections and ensure they can lead a normal life.

 

Conditions where the immune system is out of balance are generally referred to as immune-mediated diseases, of which auto-immune diseases are a well-known subgroup. Such conditions may lead to various diseases, including bleeding disorders with a reduced number of blood platelets (immune thombocytopenic purpura (ITP)) and inflammatory neurologic conditions such as Guillain-Barré-Syndrome (GBS), chronic demyelinating polyradiculoneuropathy (CIDP) or multiple sclerosis (MS). Many other organ systems can also be a target of an immune-mediated disease.

 

Immunotherapy treats immune diseases and deficiencies by inducing, enhancing, or suppressing an immune response through immunomodulation or immunoglobulin replacement therapy.

 

Indications for Octapharma's immunotherapy products

  • Primary Immunodeficiency (PID)
  • Myeleoma and chronic lymphatic leukaemia (CLL) with severe secondary hypogrammaglobulinaemia
  • Immune thrombocytopenic purpura (ITP)
  • Kawasaki disease
  • Guillain Barre Syndrome (GBS)
  • Children with congenital AIDS and recurrent infections
  • Allogeneic bone marrow transplantation