Human Albumin is widely used as an excipient in drug formulation, as a component of cell culture media, for drug delivery, cryopreservation of cells, vaccine manufacturing, or coating of medical devices; ultimately making it a versatile agent in pharmaceutical and biotechnological products.1-3
In addition to Albumin’s use as a stabilizer in liquid and lyophilized protein solutions, it has long been used in both research and commercial settings as a component of growth media and tissue culture.1,4
The usefulness of Albumin as a component of media is that it is incorporated into cell culture in conjunction with growth factors and other peptides. In addition, Albumin can bind to the outer surface of the cell membrane through non-specific adsorption, thereby providing cell protection. This role is particularly evident in bioreactors, where Albumin prevents physical damage to cells caused by hydrodynamic stress.
Albumin is also used successfully as a stabilizer in a variety of vaccines5, including vaccines against rabies, TBE and measles, mumps and rubella.